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Amlodipine besilate


Amlodipine besilate
Product name : Amlodipine besilate
Item : RX050
Details :
 Chinese name: benzene sulfonic acid amlodipine
English synonyms: 2 [(2 - amino ethoxy) methyl] - (2 - chlorobenzene base) - 3-4 b formyl formyl - 5 - methyl oxygen - 6 - methyl - 1, 4-2 hydrogen pyridine benzene sulfonate;Benzene sulfonic acid amlodipine.3 - ethyl - 5 - methyl - 2 - (2 - amino ethyl methyl oxygen) - 4 - (2 - chlorobenzene) - 1, 4 - dihydro - 6 - methyl - 3, 5 - pyridine dicarboxylic acid ester benzene sulfonate;Benzene sulfonic acid amlodipine (complex living xi, jay van andel);Benzene sulfonic acid amlodipine (standard);Benzene sulfonic acid amlodipine (benzene sulfonic acid amine chloride horizon, winding live happiness, jay van andel);Arrow horizon sulfonate
English name: Amlodipine besilate
CAS no. : 111470-99-6
Molecular formula: C26H31ClN2O8S
Molecular weight: 567.05
Related categories: aromatic hydrocarbons;Active pharmaceutical ingredients.Cardiovascular research apis;Enzyme inhibitor.Pharmaceutical raw materials;Small molecule inhibitors
Standard: enterprise standard
Medical grade levels:
Content: 99%
Packing: 25 kg/plastic drum can be broken up
Ingredients: benzene sulfonic acid amlodipine was 99%
The physical and chemical properties
Melting point: 199-201 ° C
Storage conditions: avoid light, shade seal preservation
Solubility: DMSO: 20 mg/mL
Solubility: soluble in methanol, slightly soluble in water, soluble in DMSO (20 mg/ml), water (10 mm), chloroform, ethanol and methanol (14 mg/ml).
Appearance: white powder
Pharmacology: benzene sulfonic acid amlodipine is two hydrogen pyridine class calcium antagonists (calcium antagonists or slow channel blockers).Cardiac and smooth muscle contraction depends on extracellular calcium ions through specific ion channel into the cells.This product selective inhibition of calcium ions across the membrane into the smooth muscle cells and myocardial cells, the smooth muscle function is greater than the heart muscle.Its interaction with calcium channel is determined by its and receptor sites in combination with settlement from the progressive rate, thus gradually produce pharmacological effects.This product is peripheral artery KuoZhangJi, direct effects on vascular smooth muscle, reduce the peripheral vascular resistance, reducing blood pressure.Treatment doses, negative inotropic effect was observed in vitro experiment, but not seen in the whole animal experiment.This product does not affect the plasma calcium concentration.15 randomized, double-blind, placebo-controlled clinical trials confirmed that the antihypertensive effect of this product.Mild-to-moderate hypertension patients daily medication time, 24 hours can reduce the recumbent position and blood pressure, long-term use does not cause a significant change in heart rate or plasma catecholamine.Antihypertensive effect is stable, peak value.Antihypertensive effect and dose related, step-down associated with blood pressure before treatment, moderate hypertension (105-114 MMHG), diastolic blood pressure than the effect of mild hypertension (90-104 MMHG), diastolic blood pressure, high blood pressure is normal no obvious effect after taking this medicine.This product reduce the diastolic blood pressure are of a similar function in the elderly and young people is stronger, the role of the lower systolic blood pressure on the elderly this product as the calcium ion of biological agent, block myocardial and vascular smooth muscle cell calcium ion by calcium ion channels of the cell membrane into the cell.Directly to relax vascular smooth muscle, have antihypertensive effect, this product is through a small peripheral artery in the expansion, relieve angina make peripheral resistance is reduced, thus reducing myocardial oxygen consumption, and expansion of normal and ischemic OuDeGuan artery and coronary arterioles, made the coronary artery spasm patient myocardial oxygen increased.


Use: this product is suitable for the treatment of high blood pressure.Can be used alone or in combination with other anti-hypertensive drugs combined use of;Chronic stable angina


Usage and dosage: 1, the adult: usually treat hypertension starting dose of 5 mg, once per day, maximum dose of 10 mg once daily.
2, the figure is small, weak, old, or with patients with hepatic insufficiency, starting dose of 2.5 mg, once per day.This dose can also be for this product in combination with other antihypertensive drug treatment dose.Dose adjustment should be performed according to individual patients response
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